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首都医科大学

英文名：Capital Medical University 简称：“首医”,“首医大”,“CMU” 所在地：北京 院校代码：10025 类型：文科类/理科类/医药类/考研院校

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李俊发
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人物简历
首都医科大学研究生指导教师简介
　　首都医科大学研究生指导教师简介
　　姓名：李俊发性别：男职称：教授
　　职务：系常务副主任招生院所：基础医学院
　　招生类型：科学学位(博) 科学学位(硕)
　　招生专业：神经生物学(博) 神经生物学(硕)
　　研究方向名称：脑缺血/低氧损伤和适应机制研究
　　电子信箱：junfali@ccmu.edu.cn
　　社会任职
　　1. 中国生理学会理事
　　2. 北京生理科学会秘书长
　　3. 《生理通讯》副主编
　　4. 《基础医学与临床》常务编委
　　5. 《中华眼底病杂志》编委
　　6. 中国生物化学和分子生物学会、中国生理学会、北京生理科学会、北京神经科学会等学术团体会员
　　7. 《生理学报》《生理科学进展》《中华医学杂志》《中国科技论文在线》和《自然科学进展》等国内杂志审稿专家
　　8. Neurobiol Dis, Brain Res, Neurosci Lett, Eur J Anaesth, J Neurosci Meth, J Neurosci Res, Cell Mol Biol Lett等SCI杂志审稿专家
　　9. 中国神经科学学会教育与继续教育工作委员会 委员
　　个人简历
　　1. 198109-198608:首都医科大学 医学学士
　　2. 198608-198908:北京医学高等专科学校(现首都医科大学燕京医学院) 助教，兼校团委书记
　　3. 198908-199206:中国协和医科大学 医学硕士
　　4. 199206-199602:北京医学高等专科学校(现首都医科大学燕京医学院) 讲师，兼教务处副处长
　　5. 199602-200102:美国国立卫生研究院(NIH) 访问学者
　　6. 200102-200612:首都医科大学神经生物学系 副研究员/副教授、副主任
　　7. 200308-200607:首都医科大学 神经生物学博士
　　8. 200501-200912:首都医科大学分子生物学实验测试室 主任
　　9. 200701-200712:首都医科大学神经生物学系 教授、博导、副主任
　　10. 200801- :首都医科大学神经生物学系 教授、博导、常务副主任
　　重要学术论文
　　1. Shu L, Li T, Han S, Ji F, Pan C, Zhang B, Li J (李俊发)*.Inhibition of neuron-specific CREB dephosphorylation is involved in Propofol and Ketamine-induced neuroprotection against cerebral ischemic injuries of mice. Neurochemical Research. 2012,37:49-58.SCI
　　2. Shi Y, Wang C, Han S, Pang B, Zhang N, Wang J, Li J (李俊发)*.Determination of PKC isoform-specific protein expression in pulmonary arteries of rats with chronic hypoxia-induced pulmonary hypertension. Medical Science Monitor. 2012,18(2):BR69-75.SCI
　　3. Liu C, Peng Z, Zhang N, Yu L, Han S, Li D, Li J (李俊发)*.Identification of differentially expressed microRNAs and their PKC-isoform specific gene network prediction during hypoxic preconditioning and focal cerebral ischemia of mice. Journal of Neurochemistry. 2012,120:830-841.SCI
　　4. Li Z, Li J (李俊发), Bu X, Liu X, Tankersley CG, Wang C, Huang K.Age-induced augmentation of p38 MAPK phosphorylation in mouse lung. Experimental Gerontology. 2011,46:694-702.SCI
　　5. Bu X, Zhang N, Yang X, Liu Y, Du J, Liang J, Xu Q, Li J (李俊发)*.Proteomic analysis of cPKCbetaII-interacting proteins involved in HPC-induced neuroprotection against cerebral ischemia of mice. Journal of Neurochemistry. 2011,117(2):346-356.SCI
　　6. Zhang N, Yin Y, Han S, Jiang J, Yang W, Bu X, Li J (李俊发)*.Hypoxic preconditioning induced neuroprotection against cerebral ischemic injuries and its cPKCgamma-mediated molecular mechanism. Neurochemistry International. 2011,58(6):684-692.SCI
　　7. Wang Y, Mu X, Wu J, Wu A, Fang L, Li J (李俊发)*, Yue Y.Differential Roles of Phosphorylated AMPA Receptor GluR1 Subunits at Serine-831 and Serine-845 Sites in Spinal Cord Dorsal Horn in a Rat Model of Post-Operative Pain. Neurochemical Research. 2011,36(1):170-176.SCI
　　8. Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, Zhang B, Han T, Zhu YB, Yin DM, Li J (李俊发), Zhou Z, Wang KW, Wang Y.The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. Journal of Neuroscience. 2010,30(22):7575-7586.SCI
　　9. Cui W, Li Y, Li S, Wang R, Li J(李俊发)*.Systemic administration of lidocaine reduces morphine requirements and postoperative pain of patients undergoing thoracic surgery after propofol-remifentanil-based anaesthesia. European Journal of Anesthesiology. 2010,27(1):41-46.SCI
　　10. Qu Y, Shi X, Zhang H, Sun W, Han S, Yu C, Li J(李俊发)*.VCAM-1 siRNA reduces neointimal formation after surgical mechanical injury of the rat carotid artery. Journal of Vascular Surgery. 2009,50(6):1452-1458.SCI
　　11. Ding J, Ding N, Wang N, Lu Q, Lu N, Yang D, Bu X, Han S, Li J(李俊发)*.Determination of conventional protein kinase C isoforms involved in high intraocular pressure-induced retinal ischemic preconditioning of rats. Vision Research. 2009,49(3):315-321.SCI
　　12. Wang Y, Wen Y, Fang Y, Pang H, Guo Z, Shi L, Li J(李俊发).Experimental vasoprotection by a novel erythrocyte-derived depressing factor in rats with arterial calcinosis. Vascul Pharmacol. 2009,50(1-2):65-70.SCI
　　13. Cui X, Li J(李俊发)*, Li T, Ji F, Bu X, Zhang N, Zhang B.Propofol and ketamine induced anesthetic depth-dependent decrease of CaMKII phosphorylation levels in rat hippocampus and cortex. Journal of Neurosurgical Anesthesiology. 2009,21(2):145-154.SCI
　　14. Cui W, Li Y, Li S, Yang W, Jiang J, Han S, Li J(李俊发)*.Systemic lidocaine inhibits remifentanil-induced hyperalgesia via the inhibition of cPKCgamma membrane translocation in spinal dorsal horn of rats. Journal of Neurosurgical Anesthesiology. 2009,21(4):318-325.SCI
　　15. Jiang J, Yang W, Huang P, Bu X, Zhang N, Li J(李俊发)*.Increased phosphorylation of Ets-like transcription factor-1 in neurons of hypoxic preconditioned mice. Neurochemical Research. 2009,34:1443-1450.SCI
　　16. Wu J, Zhang X, Nauta HJ, Lin Q, Li J(李俊发)*, Fang L.JNK1 regulates histone acetylation in trigeminal neurons following chemical stimulation. Biochem. Biophys. Res Commun.. 2008,376:781-786.SCI
　　17. Liu Y, Li J(李俊发)*, Yang J, Ji F, Bu X, Zhang N, Zhang B.Inhibition of PKCgamma membrane translocation mediated morphine preconditioning-induced neuroprotection against oxygen-glucose deprivationin the hippocampus slices of mice. Neuroscience Letters. 2008,444(1):87-91.SCI
　　18. Qi X, Lin W, Li J(李俊发), Li H, Wang W, Wang D, Sun M.Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress. Neurobiology of Disease. 2008,31(2):278-285.SCI
　　19. Zhang N, Gao G, Bu X, Han X, Fang L, Li J(李俊发)*.Neuron-specific phosphorylation of c-Jun N-terminal kinase increased in the brain of hypoxic preconditioned mice. Neuroscience Letters. 2007,423(3):219-224.SCI
　　20. Wei Y, Wang N*, Lu Q, Zhang N, Zheng D, Li J(李俊发)*.Enhanced protein expressions of sortilin and p75NTR in retina of rat following elevated intraocular pressure-induced retinal ischemia. Neuroscience Letters. 2007,429(2-3):169-174.SCI
　　21. Huang P, Qi Z, Bu X, Zhang N, Han S, Fang L, Li J(李俊发)*.Neuron-specific phosphorylation of mitogen- and stress-activated protein kinase-1 involved in cerebral hypoxic preconditioning of mice. Journal of Neuroscience Research. 2007,85(6):1279-1287.SCI
　　22. Wu J, Su G, Ma L, Zhang X, Lei Y, Lin Q, Nauta HJ, Li J(李俊发)*, Fang L.The role of c-AMP-dependent protein kinase in spinal cord and post synaptic dorsal column neurons in a rat model of visceral pain. Neurochemistry International. 2007,50(5):710–718.SCI
　　23. Jia J, Wang X, Li H, Han S, Zu P, Li J(李俊发)*.Activations of nPKCe and ERK1/2 were involved in oxygen-glucose deprivation induced neuroprotection via NMDA receptors in hippocampal slices of mice. Journal of Neurosurgical Anesthesiology. 2007,19(1):18-24.SCI
　　24. Kadekaro M, Su G, Chu R, Lei Y, Li J(李俊发)*, Fang L.Effects of nitric oxide on expressions of nitrosocysteine and calcium-activated potassium channels in the supraoptic nuclei and neural lobe of dehydrated rats. Neuroscience Letters. 2007,411(2):117-122.SCI
　　25. Qi Z, Bu X, Huang P, Zhang N, Han S, Fang L, Li J(李俊发)*.Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice. Neurochemical Research. 2007,32(9):1450-1459.SCI
　　26. Bu X, Huang P, Qi Z, Zhang N, Han S, Fang L, Li J(李俊发)*.Cell type-specific activation of p38 mitogen-activated protein kinases in the brain regions of hypoxic preconditioned mice. Neurochemistry International. 2007,51(8):459-466.SCI
　　27. Wu J, Li J(李俊发), Lin Q, Fang L.Signal transduction in chronic pain. International Anesthesiology Clinics. 2007,45(2):73-81.
　　28. Li J(李俊发)*, Yang C, Han S, Zu P, Wu J, Xu Q, Fang L.Increased phosphorylation of neurogranin in the brain of hypoxic preconditioned mice. Neuroscience Letters. 2006,391(3):150-153.SCI
　　29. Kadekaro-M，Su G，Chu R，Lei Y，Li J(李俊发)*，Fang L.Nitirc oxide up-regulates the expression of calcium-dependent potassium channels in thesuproptic nuclei and neueal lobe of rats following dehdration. Neuroscience Letters. 2006,404(1-2):50-55.SCI
　　30. Li J(李俊发)* , Qu Y, Zu P, Han S, Gao G, Xu Q, Fang L.Increased isoform-specific membrane translocation of conventional and novel protein kinase C in human neuroblastoma SH-SY5Y cells following prolonged hypoxia. Brain Research. 2006,1093(1):25-32.SCI
　　31. Meng F, Li J(李俊发), Zhang B, Ji F.nPKCe and NMDA receptors participate in neuroprotection induced by morphine pretreatment. Journal of Neurosurgical Anesthesiology. 2006,18(2):119-124.SCI
　　32. Long C, Gao Y, Gao G, Han S, Zu P, Fang L, Li J(李俊发)*.Decreased phosphorylation and protein expression of ERK1/2 in the brain of hypoxic preconditioned mice. Neuroscience Letters. 2006,397(3):307-312.SCI
　　33. Gao Y, Gao G, Long C, Han S, Zu P, Fang L, Li J(李俊发)*.Enhanced phosphorylation of cyclic AMP response element binding protein in the brain of mice following repetitive hypoxic exposure. Biochemical and Biophysical Research Communications. 2006,340(2):661-667.SCI
　　34. Qi X, Lin W, Li J(李俊发), Pan Y, Wang W.The depressive-like behaviors are correlated with decreased phosphorylation of mitogen-activated protein kinases in rat brain following chronic forced swim stress. Behavioural Brain Research. 2006,175(2):233-240.SCI
　　35. Zhao L, Wang N, Jiang L, Long C, Li J(李俊发)*.Unilateral optic nerve transection up-regulate Hsp70 protein expression in lateral geniculate nucleus of rats. Neuroscience Letters. 2006,404(1-2):44-49.SCI
　　36. Wu J, Su G, Ma L, Zhang X, Lei Y, Li J(李俊发), Lin Q, Fang L.Protein kinases mediate increment of the phosphorylation of cyclic AMP-responsive element binding protein in spinal cord of rats following capsaicin injection. Molecular Pain. 2005,1:26-34.SCI
　　37. Li J(李俊发)*, Niu C, Han S, Zu P, Li H, Xu Q, Fang L.Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice. Brain Research. 2005,1060(1-2):62-72.SCI
　　38. Niu C, Li J(李俊发)*, Cui X, Han S, Zu P, Li H, Xu Q.Changes in cPKC isoform-specific membrane translocation and protein expression in the brain of hypoxic preconditioned mice. Neuroscience Letters. 2005,384(1-2):1-6.SCI
　　39. Huang KP, Huang FL, Jager T, Li J(李俊发), Reymann KG, Balschun D.Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling. Journal of Neuroscience. 2004,24(47):10660-10669.SCI
　　40. Wu J, Li J(李俊发), Huang KP, Huang FL.Attenuation of protein kinase C and camp-dependent protein kinase signal transduction in the neurogranin knockout mouse. Journal of Biological Chemistry. 2002,277(22):19498-19505.SCI
　　41. Li J(李俊发), Huang FL and Huang KP.Glutathiolation of proteins by glutathione disulfide S-oxide derived from S-nitrosoglutathione. Modifications of rat brain neurogranin/RC3 and neuromodulin/GAP-43. Journal of Biological Chemistry. 2001,276(5):3098-3150.SCI
　　42. Huang KP, Huang FL, Li J(李俊发), Schuck P, McPhie P.Calcium-sensitive interaction between calmodulin and modified forms of rat brain neurogranin/RC3. Biochemistry. 2000,39(24):7291-7299.SCI
　　43. Pak JH, Huang FL, Li J(李俊发), Balschun D, Reymann KG, Chiang C, Westphal H, and Huang KP.Involvement of neurogranin in the modulation of calcium/calmodulin- dependent protein kinase II, synaptic plasticity, and spatial learning: A study with knockout mice. Proc Natl Acad Sci U S A (PNAS). 2000,97(21):11232-11237.SCI
　　44. Liu J, He L, Collins I, Ge H, Libutti D, Li J(李俊发), Egly J, and Levens D.The FBP interacting repressor targets TFIIH to inhibit activated transcription. Molecular Cell. 2000,5:331-341.SCI
　　45. Li J(李俊发), Pak JH, Huang FL and Huang KP.N-methyl-D-aspartate induces neurogranin/RC3 oxidation in rat brain slices. Journal of Biological Chemistry. 1999,274(3):1294-1300.SCI
　　主编或副主编的著作/译著
　　1. 《细胞信号转导研究技术》,主编,中国协和医科大学出版社,200808
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